All Roads Lead to IKKɛ

نویسنده

Reuven Agami

چکیده

During malignant transformation, cancer cells acquire genetic alterations that surmount the normal controls regulating proliferation and cell survival. High-resolution comparative genomic analyses reveal that genomic instability is a hallmark of cancer development and that cancer-causing mutations are only a tiny fraction of the genetic modifications, most of which are “bystander” mutations. Thus, the discovery of the genetic alterations that contribute to tumor formation is crucial to the rational design of cancer therapeutics. But how can we distinguish cancer-causing mutations from other more benign mutations, and how do we identify genes whose activities either promote tumor development or protect us from cancer? In a report in this issue, Boehm et al. (2007) combine two functional genetic screens together with data from comparative genomic analyses to identify new protein kinases that promote tumor formation (Figure 1). These efforts have led to the identification of a new oncogene in breast cancer, IKBKE (I-kappa-B kinase epsilon), which encodes IKKε, an upstream regulator of the transcription factor NF-κB.

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